A guitar he used in the 2005 Cream reunion shows in London and New York and more than other 70 instruments are up for grabs.
Lots start at a guide price of £190 but the Fender Stratocaster, valued at up to £19,000, will be the star buy.
A rehab clinic the 65-year-old founded in Antigua will get all the proceeds from this auction.
A spokesman for Bonhams which is holding the sale in New York in March 2011 said that ‘The instruments are a part of his history but most are affordable.’
Instruments and amps by Gibson, Fender, Marshall, Martin and Music Man are included in the sale.
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